Analysis of microsatellite aberrations and loss of heterozygosity in follicular lymphoma, diffuse large B-cell lymphoma, and high-grade B-cell lymphoma patients

Background . The study of genetic predictors non-Hodgkin’s lymphomas prognosis is one the most relevant areas oncohematology. It extremely interesting to search for integral markers that reflect important stages tumor pathogenesis. DNA repair system plays key roles in genomic instability. Aberrations microsatellite repeats such as instability (MSI), particular elevated alterations at selected tetranucleotide (EMAST) characteristic mismatch and loss heterozygosity (LOH) an feature Objective Analysis MSI, EMAST, LOH significance follicular lymphoma (FL), diffuse large B-cell (DLBCL), high-grade (HGBL) patients. Materials methods was performed by multiplex PCR fragment analysis with diagnostic panels COrDIS Plus MSI 85 FL patients, 32 DLBCL 37 HGBL Results frequency general group 40/81 (49.4 %), – 10/82 (12.2 EMAST 15/81 (18.5 %). 21/31 (67.8 11/37 (29.7 13/31 (41.9 18/29 (62.0 5/32 (15.6 14/32 (43.8 When considering morphological types FL, it noted a higher aberrations more aggressive morphology (p <0.05). identifies patients unfavorable prognosis. allows identifying additional LOH+ cohort early events low EFS. Conclusion have prognostic value HGBL. No associations survival were observed DLBCL. Changes mononucleotide did not correspond MSI-H solid tumors. For this reason, clinical consequences neoplasms, efficacy immune checkpoint inhibitors, cannot be expected replicated solely on basis detection.